DIGOXIN EFFECT ON ECG (OVERVIEW)

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 DIGOXIN - CARDIAC GLYCOSIDES (BASICS)

HELPS,THE HEART TO PUMP MORE EFFICIENTLY, INHIBITS NORMAL FUNCTION OF Na+/K+ PUMP.

HOW DOES IT AFFECTS THE HEART[ POSITIVE AND NEGATIVE EFFECTS]

POSITIVE:INOTROPIC EFFECT ON THE HEART: SQEEZES/CONTRACTS HARDER.

NEGATIVE: CHRONOTROPIC EFFECT ON THE HEART: BEATS SLOWER.

NEGATIVE: DROMOTROPIC EFFECT ON THE HEART; SLOWS IMPULSES SENT THROUGH                          AV NODE

RESULTS; 

HEART SQEEZES MORE BLOOD OUT = INCREASED STROKE VOLUME = INCREASED CARDIAC OUTPUT

DRUG USED FOR:

HEART FAILURE, CARDIOGENIC SHOCK, A.FIB, A.FLUTTER.

EFFECT ON ECG:

THE ADMINISTRATION OF DIGOXIN CAUSES (T-WAVE) INVERSION - CHARACTERISTICALLY WITH SLOPING DEPRESSION OF THE ST SEGMENT.

IT IS HELPFUL TO RECORD AN ECG BEFORE GIVING DIGOXIN, TO SAVE LATER CONFUSION ABOUT THE SIGNIFICANCE OF T-WAVE CHANGES.


THERAPEUTIC:

0.5 - 2 ng/ml (ANYTHING GREATER THAN  2ng  IT'S CONSIDER TOXIC)

ANTIDOTE: DIGIBIND

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